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Dynamic Mechanical Interaction between Aqueous Humor and Iris

Research Fellow: Cristiano Oliveira, M.D.

Study in conjunction with the Department of Biomedical Engineering, University of Minnesota. The purpose of the study project is to quantify the short-term dynamic response of the iris to changes in pupil diameter and accommodation. For that a total of 120 patients with abnormal iris contours (narrow angle, pigment dispersion syndrome, or pigmentary glaucoma) will be examined in a combined study of dynamic iris response. Ultrasound biomicroscopy (UBM) will be used to record changes in the iris contour of pigment dispersion syndrome and pigmentary glaucoma subjects before and after accommodation. Similar measurements will be made on narrow angle subjects in response to darkening of the room, again with the intent of characterizing the dynamic response. Characterizing the short-term dynamics of iris contour will lead to better understanding of the mechanisms underlying PDS, PG, and ACG. We hope that this improved understanding will in turn lead to better diagnostic and therapeutic strategies.

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